U.S. vaccine experts: the efficacy of the new crown vaccine on obese people may be poor

A novel coronavirus pneumonia vaccine novel coronavirus pneumonia is not recommended for obese people, but it is one of the high-risk groups for new crown pneumonia,

warned recently. According to ABC News on August 13, Matthew Lawrence, chief researcher at the University of Maryland, points out that his team collected data on other vaccines tested in obese people and found that vaccines were ineffective in obese people. Lawrence also recently participated in the new crown vaccine trial of Modena company. ABC pointed out that this is one of the most advanced trials of new crown vaccine in the United States. In response, the Centers for Disease Control and prevention of the United States also said that obese people are more likely to become infected with the new coronavirus and are more likely to die as a result. At present, more than a third of the population in the United States is obese. < / P > < p > for a long time, a number of studies have shown that the efficacy of a variety of vaccines for obese adults is not as good as that for non obese people, including vaccines against viral influenza and hepatitis B, as well as tetanus and rabies caused by other pathogenic organisms. The evidence for the low efficacy of the vaccine in obese people can be traced back to 1985. At that time, hundreds of hospital employees in North Carolina were vaccinated against hepatitis B. the researchers found that those with a higher BMI were twice as likely to fail immunization than those with lower BMI, which meant that the vaccine did not provide sufficient protection against hepatitis B. The general lack of efficacy of < / P > < p > vaccines for obese people has caused concern among experts. “We recognize that although we are developing a new coronal vaccine, it may not be applicable to all populations. This is a worrying issue. ” Lawrence said. < / P > < p > it is not clear why vaccines are less effective in obese patients. One hypothesis is that the conventional one inch needle used for immunization is not long enough for obese people. This is because the subcutaneous fat layer of obese people is thick, which makes the needle unable to reach the muscle under the fat layer, and the vaccine solution needs to stay in the muscle to achieve its best effect. Another hypothesis is that obese adults may need a higher dose or even an enhanced version of the vaccine to elicit a response from their immune system to resist the virus because of their large weight. The third hypothesis is related to the immune system of obese patients. Leonard freyland, vice president and director of Scientific Affairs and public health at GlaxoSmithKline, said obesity can cause some chronic inflammation that may hinder the effectiveness of the vaccine. < p > < p > < p > the only way to find out whether the new crown vaccine works in obese people is to include obese people in a large-scale phase III clinical trial. Dr. Arthur Kaplan of New York University’s Langone Medical Center said: “it’s important to recruit obese people to the trial because they are likely to have chronic diseases. “。 Historically, obese people have been excluded from vaccine trials because of chronic diseases such as diabetes and hypertension. Privacy Policy

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